Hybrid generative adversarial network based on frequency and spatial domain for histopathological image synthesis.
Journal:
BMC bioinformatics
PMID:
39871140
Abstract
BACKGROUND: Due to the complexity and cost of preparing histopathological slides, deep learning-based methods have been developed to generate high-quality histological images. However, existing approaches primarily focus on spatial domain information, neglecting the periodic information in the frequency domain and the complementary relationship between the two domains. In this paper, we proposed a generative adversarial network that employs a cross-attention mechanism to extract and fuse features across spatial and frequency domains. The method optimizes frequency domain features using spatial domain guidance and refines spatial features with frequency domain information, preserving key details while eliminating redundancy to generate high-quality histological images.