Ulcerative Colitis Severity Classification and Localized Extent (UC-SCALE): An Artificial Intelligence Scoring System for a Spatial Assessment of Disease Severity in Ulcerative Colitis.

Journal: Journal of Crohn's & colitis
PMID: 39657580

Abstract

BACKGROUND AND AIMS: Validated scoring methods such as the Mayo Clinic Endoscopic Subscore (MCES) evaluate ulcerative colitis (UC) severity at the worst colon segment, without considering disease extent. We present the Ulcerative Colitis Severity Classification and Localized Extent (UC-SCALE) algorithm, which provides a comprehensive and automated evaluation of endoscopic severity and disease extent in UC.

Authors

  • Benjamín Gutiérrez-Becker
    Roche Pharma Research and Early Development, Informatics, Roche Innovation Center Basel, Basel, Switzerland. Electronic address: benjamin.gutierrez_becker@roche.com.
  • Stefan Fraessle
    Roche, Pharma Research & Early Development, Data and Analytics, Basel, Switzerland.
  • Heming Yao
    gRED Computational Science, Genentech, Inc., South San Francisco, California.
  • Jerome Luscher
    Biology Research AI Development (BRAID), Genentech Research and Early Development, San Francisco, CA, USA.
  • Rafal Girycki
    Future Processing, Gliwice, Poland.
  • Bartosz Machura
    Future Processing, Bojkowska 37A, 44-100 Gliwice, Poland. Electronic address: bmachura@future-processing.com.
  • Janusz Czornik
    Graylight Imaging, Gliwice, Poland.
  • Jaroslaw Goslinsky
    Graylight Imaging, Gliwice, Poland.
  • Marek Pitura
    Graylight Imaging, Gliwice, Poland.
  • Steven Levitte
    Roche, Product Development Clinical Science, Technology and Translational Research, Basel, Switzerland.
  • Josep Arús-Pous
    Hit Discovery, Discovery Sciences, R&D, AstraZeneca, Pepparedsleden 1, Gothenburg 43183, Sweden.
  • Emily Fisher
    Roche, Product Development Clinical Science, Technology and Translational Research, Basel, Switzerland.
  • Daniela Bojic
    Roche, Product Development Clinical Science, Technology and Translational Research, Basel, Switzerland.
  • David Richmond
    Roche, Product Development Clinical Science, Technology and Translational Research, Basel, Switzerland.
  • Amelie E Bigorgne
    Roche, Product Development Clinical Science, Technology and Translational Research, Basel, Switzerland.
  • Marco Prunotto
    Pharma Research and Early Development (pRED), Roche Innovation Center Basel, Basel, Switzerland.

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