Cooperative Magnetic Interfacial Microrobot Couple for Versatile Non-Contact Biomedical Applications.

Journal: Advanced materials (Deerfield Beach, Fla.)
PMID: 39967348

Abstract

Magnetic interfacial microrobots are increasingly recognized as a promising approach for potential biomedical applications ranging from electronic functionalization to minimally invasive surgery and targeted drug delivery. Nevertheless, existing research faces challenges, including less cooperative interactions, contact-based cargo manipulation, and slow transport velocity. Here, the cooperative magnetic interfacial microrobot couple (CMIMC) is proposed to address the above challenges. The CMIMC can be maneuvered by a single magnet and readily switched between capture and release states. By leveraging cooperative interactions and meticulous engineering of capillary forces through shape design and surface treatment, the CMIMC demonstrates the ability to perform non-contact cargo manipulation. Using the synergy of preferred magnetization directions and magnetic field distribution, along with optimization of the resistance-reducing shape, the CMIMC significantly enhances the cargo transport velocity, reaching 12.2 body length per second. The studies demonstrate various biomedical applications like targeted drug delivery and myomectomy, paving the way for the broad implementation of interfacial microrobots in biomedical fields.

Authors

  • Bowen Chen
    Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Hao Wu
    Zhejiang Institute of Tianjin University (Shaoxing), Shaoxing, China.
  • Yiyu Chen
    Department of Laboratory Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, P.R. China.
  • Kangru Cheng
    CAS Key Laboratory of Mechanical Behavior and Design of Materials, Key Laboratory of Precision Scientific Instrumentation of Anhui Higher Education Institutes, Department of Precision Machinery and Precision Instrumentation, University of Science and Technology of China, Hefei, 230027, China.
  • Ying Zhou
    Institute of Drug Metabolism and Pharmaceutical Analysis, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China.
  • Juan Zhang
    Guangdong R & D Center for Technological Economy RM. 802, Guangzhou, Guangdong, P.R. China.
  • Chaowei Wang
    CAS Key Laboratory of Mechanical Behavior and Design of Materials, Key Laboratory of Precision Scientific Instrumentation of Anhui Higher Education Institutes, Department of Precision Machinery and Precision Instrumentation, University of Science and Technology of China, Hefei, 230027, China.
  • Jiawen Li
    Institute for Photonics and Advanced Sensing, The University of Adelaide Adelaide SA Australia.
  • Dong Wu
  • Jiaru Chu
    Hefei National Laboratory for Physical Sciences at the Microscale, Key Laboratory of Precision Scientific Instrumentation of Anhui Higher Education Institutes, CAS Key Laboratory of Mechanical Behavior and Design of Materials, Department of Precision Machinery and Precision Instrumentation, University of Science and Technology of China, Hefei 230026, China.
  • Yanlei Hu
    Hefei National Laboratory for Physical Sciences at the Microscale, Key Laboratory of Precision Scientific Instrumentation of Anhui Higher Education Institutes, CAS Key Laboratory of Mechanical Behavior and Design of Materials, Department of Precision Machinery and Precision Instrumentation, University of Science and Technology of China, Hefei 230026, China.

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