M-DeepAssembly: enhanced DeepAssembly based on multi-objective multi-domain protein conformation sampling.

Journal: BMC bioinformatics
PMID: 40325375

Abstract

BACKGROUND: Association and cooperation among structural domains play an important role in protein function and drug design. Despite remarkable advancements in highly accurate single-domain protein structure prediction through the collaborative efforts of the community using deep learning, challenges still exist in predicting multi-domain protein structures when the evolutionary signal for a given domain pair is weak or the protein structure is large.

Authors

  • Xinyue Cui
    College of Information Engineering, Zhejiang University of Technology, Hangzhou 310023, Zhejiang, China.
  • Yuhao Xia
    College of Information Engineering, Zhejiang University of Technology, Hangzhou 310023, Zhejiang, China.
  • Minghua Hou
    College of Information Engineering, Zhejiang University of Technology, Hangzhou 310023, China.
  • Xuanfeng Zhao
    College of Information Engineering, Zhejiang University of Technology, Hangzhou, 310023, China.
  • Suhui Wang
    College of Information Engineering, Zhejiang University of Technology, Hangzhou, 310023, China.
  • Guijun Zhang
    College of Information Engineering, Zhejiang University of Technology, Hangzhou 310023, China. Electronic address: zgj@zjut.edu.cn.

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