Closing the gap in the clinical adoption of computational pathology: a standardized, open-source framework to integrate deep-learning models into the laboratory information system.

Journal: Genome medicine
Published Date:

Abstract

BACKGROUND: Digital pathology (DP) has revolutionized cancer diagnostics and enabled the development of deep-learning (DL) models aimed at supporting pathologists in their daily work and improving patient care. However, the clinical adoption of such models remains challenging. Here, we describe a proof-of-concept framework that, leveraging Health Level 7 (HL7) standard and open-source DP resources, allows a seamless integration of both publicly available and custom developed DL models in the clinical workflow.

Authors

  • Miriam Angeloni
    Institute of Pathology, University Hospital Erlangen-Nürnberg, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany.
  • Davide Rizzi
    TESI Group/GPI, Milan, Italy.
  • Simon Schoen
    Institute of Pathology, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany.
  • Alessandro Caputo
    Department of Medicine and Surgery, University of Salerno, Salerno, Italy.
  • Francesco Merolla
    Department of Medicine and Health Sciences "V. Tiberio", University of Molise, Campobasso, Italy.
  • Arndt Hartmann
    Institute of Pathology, University Hospital of Friedrich-Alexander-University Erlangen-Nürnberg, Germany.
  • Fulvia Ferrazzi
    Institute of Pathology, University Hospital Erlangen-Nürnberg, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany.
  • Filippo Fraggetta
    Department of Pathology, Cannizzaro Hospital, 95021 Catania, Italy.