DeepAllo: allosteric site prediction using protein language model (pLM) with multitask learning.
Journal:
Bioinformatics (Oxford, England)
Published Date:
Jun 2, 2025
Abstract
MOTIVATION: Allostery, the process by which binding at one site perturbs a distant site, is being rendered as a key focus in the field of drug development with its substantial impact on protein function. The identification of allosteric pockets (sites) is a challenging task and several techniques have been developed, including Machine Learning to predict allosteric pockets that utilize both static and pocket features.