StructMAn 2.0 Web: a web server for structural annotation of protein sequences and mutations.

Journal: Nucleic acids research
Published Date: Jul 7, 2025

Abstract

StructMAn is a method for protein structural annotation. It describes each position of a protein sequence or specific variants in it in terms of their importance for the three-dimensional (3D) structure of the protein and its interactions with other molecules. StructMAn maps, aligns, and aggregates data from experimentally resolved and predicted 3D structures of proteins and their homologs for any given protein sequence and/or a combination of mutations in it. The results provide structural annotation for every amino acid position allowing a detailed structural analysis. Furthermore, StructMAn enables generation of a wide variety of position-specific high-quality structural features that can be leveraged in machine learning applications. With the new web server StructMAn 2.0 Web, we provide a user-friendly way to use StructMAn offering an easy-to-use input interface and a comprehensive visualization for the various results of StructMAn. StructMAn 2.0 Web is available at https://tools.helmholtz-hips.de/structman.

Authors

  • Alper Yurtseven
    Research Group Drug Bioinformatics, Department Drug Bioinformatics, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI), Campus E8.1, 66123 Saarbrücken, Saarland, Germany.
  • Sebastian Keller
    Research Group Drug Bioinformatics, Department Drug Bioinformatics, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI), Campus E8.1, 66123 Saarbrücken, Saarland, Germany.
  • Pascal Hirsch
    Chair for Clinical Bioinformatics, Saarland University, 66123 Saarbrücken, Saarland, Germany.
  • Olga V Kalinina
    Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI), Saarbrücken, Germany.
  • Alexander Gress
    Research Group Drug Bioinformatics, Department Drug Bioinformatics, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI), Campus E8.1, 66123 Saarbrücken, Saarland, Germany.

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