Enhancing AI-driven forecasting of diabetes burden: a comparative analysis of deep learning and statistical models.

Accurate forecasting of diabetes burden is essential for healthcare planning, resource allocation, and policy-making. While deep learning models have demonstrated superior predictive capabilities, their real-world applicability is constrained by computational complexity and data quality challenges. This study evaluates the trade-offs between predictive accuracy, robustness, and computational efficiency in diabetes forecasting. Four forecasting models were selected based on their ability to capture temporal dependencies and handle missing healthcare data: Transformer with Variational Autoencoder (VAE), Long Short-Term Memory (LSTM), Gated Recurrent Unit (GRU), and AutoRegressive Integrated Moving Average (ARIMA). Annual data on Disability-Adjusted Life Years (DALYs), Deaths, and Prevalence from 1990 to 2021 were used to train (1990-2014) and evaluate (2015-2021) the models. Performance was measured using Mean Absolute Error (MAE) and Root Mean Squared Error (RMSE). Robustness tests introduced noise and missing data, while computational efficiency was assessed in terms of training time, inference speed, and memory usage. Statistical significance was analyzed using ANOVA and Tukey's post-hoc tests. The Transformer-VAE model achieved the highest predictive accuracy (MAE: 0.425, RMSE: 0.501) and demonstrated superior resilience to noisy and incomplete data ([Formula: see text]). LSTM effectively captured short-term patterns but struggled with long-term dependencies, while GRU, though computationally efficient, exhibited higher error rates. ARIMA, despite being resource-efficient, showed limited capability in modeling long-term trends, indicating potential benefits in hybrid approaches. While Transformer-VAE provides the most accurate diabetes burden forecasting, its high computational cost and interpretability challenges limit its scalability in resource-constrained settings. These findings highlight the potential of deep learning models for healthcare forecasting, while underscoring the need for further validation before integration into real-world public health decision-making.