Use of Client-Side Machine Learning Models for Privacy-Preserving Healthcare Predictions - A Deployment Case Study.

Journal: Studies in health technology and informatics
Published Date: Sep 3, 2025

Abstract

INTRODUCTION: Machine learning (ML) and deep learning (DL) models in healthcare traditionally rely on server-centric architectures, where sensitive patient data is transmitted to external servers for processing via frameworks like Flask, raising significant privacy concerns. This work demonstrates a privacy-preserving approach by executing healthcare prediction models entirely within the web browser.

Authors

  • Yacoub Abelard Njipouombe Nsangou
    Dept. of Medical Bioinformatics, University Medical Center Göttingen, Germany.
  • Rajib Kumar Halder
    Dept. of CS and Engineering, Jagannath University, Dhaka, Bangladesh.
  • Ashraf Uddin
    School of Photovoltaic and Renewable Energy Engineering, University of New South Wales, 2052 Sydney, Australia.
  • Laurenz Engel
    Dept. of Medical Bioinformatics, University Medical Center Göttingen, Germany.
  • Fruzsina Kotsis
    Institute of Genetic Epidemiology, Department of Data Driven Medicine, Faculty of Medicine and Medical Center, University of Freiburg, Freiburg, Germany.
  • Ulla T Schultheiss
    Institute of Genetic Epidemiology, Department of Data Driven Medicine, Faculty of Medicine and Medical Center, University of Freiburg, Freiburg, Germany.
  • Johannes Raffler
    Institute for Digital Medicine, University Hospital Augsburg, Augsburg, Germany.
  • Robin Kosch
    Peter L. Reichertz Institute for Medical Informatics of TU Braunschweig, Germany.
  • Michael Altenbuchinger
    Department of Medical Bioinformatics, University Medical Center Göttingen, Göttingen, Germany.
  • Helena U Zacharias
    Peter L. Reichertz Institute for Medical Informatics of TU Braunschweig and Hannover Medical School, Hannover Medical School, 30625 Hannover, Germany.
  • Gabi Kastenmüller
    Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.
  • Jürgen Dönitz
    Dept. of Medical Bioinformatics, University Medical Center Göttingen, Germany.

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