Recognizing and Predicting Thioether Bridges Formed by Lanthionine and β-Methyllanthionine in Lantibiotics Using a Random Forest Approach with Feature Selection.

Journal: Combinatorial chemistry & high throughput screening
Published Date: Jan 1, 2017

Abstract

BACKGROUND: Lantibiotics, which are usually produced from Gram-positive bacteria, are regarded as one type of special bacteriocins. Lantibiotics have unsaturated amino acid residues formed by lanthionine (Lan) and β-methyllanthionine (MeLan) residues as a ring structure in the peptide. They are derived from the serine and threonine residues and are essential to preventing the growth of other similar strains.

Authors

  • ShaoPeng Wang
    School of Life Sciences, Shanghai University, Shanghai 200444, China.
  • Yu-Hang Zhang
    Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
  • Ning Zhang
    Institute of Nuclear Agricultural Sciences, Zhejiang University, Hangzhou, 310058, China.
  • Lei Chen
    Department of Chemistry, Stony Brook University Stony Brook NY USA.
  • Tao Huang
    The Second Clinical Medical College of Guangzhou University of Chinese Medicine, Guangzhou, China.
  • Yu-Dong Cai
    College of Life Science, Shanghai University, Shanghai, People's Republic of China.

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