Machine Learning and Molecular Dynamics Based Insights into Mode of Actions of Insulin Degrading Enzyme Modulators.

Journal: Combinatorial chemistry & high throughput screening
Published Date: Jan 1, 2017

Abstract

BACKGROUND: Alzheimer's disease (AD) is one of the most common lethal neurodegenerative disorders having impact on the lives of millions of people worldwide. The disease lacks effective treatment options and the unavailability of the drugs to cure the disease necessitates the development of effectual anti-Alzheimer drugs. Several mechanisms have been reported underlying the association of the two disorders, diabetes and dementia, one among which is the insulin-degrading enzyme (IDE) which is known to degrade insulin as well beta-amyloid peptides.

Authors

  • Salma Jamal
    School of Biotechnology, Jawaharlal Nehru University, New Delhi-110067, India phone/fax: +91-11-26738728; fax: +91-11-26702040.
  • Sukriti Goyal
  • Asheesh Shanker
    Bioinformatics Programme, Centre for Biological Sciences, Central University of South Bihar, BIT Campus, Patna, Bihar, India.
  • Abhinav Grover
    Department of Pharmacology, Lady Hardinge Medical College and Associated Hospitals, New Delhi, India.

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