[A machine learning model using gut microbiome data for predicting changes of trimethylamine-N-oxide in healthy volunteers after choline consumption].

Journal: Nan fang yi ke da xue xue bao = Journal of Southern Medical University
PMID:

Abstract

OBJECTIVE: To establish a machine learning model based on gut microbiota for predicting the level of trimethylamine N-oxide (TMAO) metabolism in vivo after choline intake to provide guidance of individualized precision diet and evidence for screening population at high risks of cardiovascular disease.

Authors

  • Jun-Qi Lu
    Department of Environmental Health, School of Public Health, Southern Medical University, Guangzhou 510515, China.E-mail: goodlujunqi@163.com.
  • Shan Wang
    Department of Echocardiography & Noninvasive Cardiology Laboratory, Sichuan Academy of Medical Sciences, Sichuan Provincial People's Hospital, Chengdu, Sichuan, 610047, China.
  • Jia Yin
  • Shan Wu
    Department of Endoscopy, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
  • Yan He
    School of Biology & Engineering, Guizhou Medical University, Guiyang, Guizhou Province, China.
  • Hui-Min Zheng
  • Hua-Fang Sheng
  • Hong-Wei Zhou