A user-guided tool for semi-automated cerebral microbleed detection and volume segmentation: Evaluating vascular injury and data labelling for machine learning.

Journal: NeuroImage. Clinical
PMID: 30140608

Abstract

BACKGROUND AND PURPOSE: With extensive research efforts in place to address the clinical relevance of cerebral microbleeds (CMBs), there remains a need for fast and accurate methods to detect and quantify CMB burden. Although some computer-aided detection algorithms have been proposed in the literature with high sensitivity, their specificity remains consistently poor. More sophisticated machine learning methods appear to be promising in their ability to minimize false positives (FP) through high-level feature extraction and the discrimination of hard-mimics. To achieve superior performance, these methods require sizable amounts of precisely labelled training data. Here we present a user-guided tool for semi-automated CMB detection and volume segmentation, offering high specificity for routine use and FP labelling capabilities to ease and expedite the process of generating labelled training data.

Authors

  • Melanie A Morrison
    Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA.
  • Seyedmehdi Payabvash
    Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA.
  • Yicheng Chen
    Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA; UCSF/UC Berkeley Graduate Group in Bioengineering, USA.
  • Sivakami Avadiappan
    Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA.
  • Mihir Shah
    Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA.
  • Xiaowei Zou
    Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA.
  • Christopher P Hess
    Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA; Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
  • Janine M Lupo
    Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA; UCSF/UC Berkeley Graduate Group in Bioengineering, USA. Electronic address: janine.lupo@ucsf.edu.

Keywords

External Resources

Popular Topics
Recent Journals