Bi-stream CNN Down Syndrome screening model based on genotyping array.

Journal: BMC medical genomics
Published Date: Nov 20, 2018

Abstract

BACKGROUND: Human Down syndrome (DS) is usually caused by genomic micro-duplications and dosage imbalances of human chromosome 21. It is associated with many genomic and phenotype abnormalities. Even though human DS occurs about 1 per 1,000 births worldwide, which is a very high rate, researchers haven't found any effective method to cure DS. Currently, the most efficient ways of human DS prevention are screening and early detection.

Authors

  • Bing Feng
    Department of Computer Science and Engineering, University of South Carolina, Columbia, 29208, South Carolina, USA.
  • William Hoskins
    Department of Computer Science and Engineering,University of South Carolina, Columbia, 29208, SC, USA.
  • Yan Zhang
    Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, 110032, China.
  • Zibo Meng
    Department of Computer Science and Engineering,University of South Carolina, Columbia, 29208, SC, USA.
  • David C Samuels
    Vanderbilt University School of Medicine,Vanderbilt University, Nashville, 37232, TN, USA.
  • Jiandong Wang
    Department of Computer Science and Engineering,University of South Carolina, Columbia, 29208, SC, USA.
  • Ruofan Xia
    Department of Computer Science and Engineering,University of South Carolina, Columbia, 29208, SC, USA.
  • Chao Liu
    Anti-Drug Technology Center of Guangdong Province, National Anti-Drug Laboratory Guangdong Regional Center, Guangzhou 510230, China.
  • Jijun Tang
    School of Computer Science and Engineering, Tianjin University, Tianjin, 300072, China. jtang@cse.sc.edu.
  • Yan Guo
    State Key Laboratory of Pathogen and Biosecurity, Beijing 100071, China.

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