Prediction of mRNA subcellular localization using deep recurrent neural networks.
Journal:
Bioinformatics (Oxford, England)
Published Date:
Jul 15, 2019
Abstract
MOTIVATION: Messenger RNA subcellular localization mechanisms play a crucial role in post-transcriptional gene regulation. This trafficking is mediated by trans-acting RNA-binding proteins interacting with cis-regulatory elements called zipcodes. While new sequencing-based technologies allow the high-throughput identification of RNAs localized to specific subcellular compartments, the precise mechanisms at play, and their dependency on specific sequence elements, remain poorly understood.