ROBOKOP KG and KGB: Integrated Knowledge Graphs from Federated Sources.

Journal: Journal of chemical information and modeling
Published Date:

Abstract

A proliferation of data sources has led to the notional existence of an implicit Knowledge Graph (KG) that contains vast amounts of biological knowledge contributed by distributed Application Programming Interfaces (APIs). However, challenges arise when integrating data across multiple APIs due to incompatible semantic types, identifier schemes, and data formats. We present ROBOKOP KG ( http://robokopkg.renci.org ), which is a KG that was initially built to support the open biomedical question-answering application, ROBOKOP (easoning ver iomedical bjects linked in nowledge-riented athways) ( http://robokop.renci.org ). Additionally, we present the ROBOKOP Knowledge Graph Builder (KGB), which constructs the KG and provides an extensible framework to handle graph query over and integration of federated data sources.

Authors

  • Chris Bizon
    Renaissance Computing Institute , University of North Carolina at Chapel Hill , Chapel Hill , North Carolina 27517 , United States.
  • Steven Cox
    Renaissance Computing Institute , University of North Carolina at Chapel Hill , Chapel Hill , North Carolina 27517 , United States.
  • James Balhoff
    Renaissance Computing Institute , University of North Carolina at Chapel Hill , Chapel Hill , North Carolina 27517 , United States.
  • Yaphet Kebede
    Renaissance Computing Institute , University of North Carolina at Chapel Hill , Chapel Hill , North Carolina 27517 , United States.
  • Patrick Wang
    CoVar Applied Technologies , Durham , North Carolina 27701 , United States.
  • Kenneth Morton
    CoVar Applied Technologies , Durham , North Carolina 27701 , United States.
  • Karamarie Fecho
    Renaissance Computing Institute , University of North Carolina at Chapel Hill , Chapel Hill , North Carolina 27517 , United States.
  • Alexander Tropsha
    Laboratory for Molecular Modeling, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, USA.