Machine learning and artificial intelligence in haematology.

Journal: British journal of haematology
Published Date: Jan 1, 2021

Abstract

Digitalization of the medical record and integration of genomic methods into clinical practice have resulted in an unprecedented wealth of data. Machine learning is a subdomain of artificial intelligence that attempts to computationally extract meaningful insights from complex data structures. Applications of machine learning in haematological scenarios are steadily increasing. However, basic concepts are often unfamiliar to clinicians and investigators. The purpose of this review is to provide readers with tools to interpret and critically appraise machine learning literature. We begin with the elucidation of standard terminology and then review examples in haematology. Guidelines for designing and evaluating machine-learning studies are provided. Finally, we discuss limitations of the machine-learning approach.

Authors

  • Roni Shouval
    Roni Shouval, Hila Mishan-Shamay, Avichai Shimoni, and Arnon Nagler, The Chaim Sheba Medical Center, Tel-Hashomer; Roni Shouval, Ori Bondi, and Ron Unger, Bar-Ilan University, Ramat-Gan, Israel; Myriam Labopin, Norbert C. Gorin, Emmanuelle Polge, Arnon Nagler, and Mohamad Mohty, European Group for Blood and Marrow Transplantation; Myriam Labopin and Mohamad Mohty, Sorbonne Universités, Centre de Recherche (CDR) Saint-Antoine; Myriam Labopin and Mohamad Mohty, Institut National de la Santé et de la Recherche Médicale, CDR Saint-Antoine; Myriam Labopin and Mohamad Mohty, Assistance Publique-Hôpitaux de Paris, Hôpital Saint-Antoine, Paris, France; Fabio Ciceri, San Raffaele Scientific Institute, Milan; Andrea Bacigalupo, Ospedale San Martino, Genoa, Italy; Jordi Esteve, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain; Sebastian Giebel, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice, Poland; Christoph Schmid, Ludwig-Maximilians-University, Munich; Nicolaus Kroger, University Medical Center Hamburg Eppendorf, Hamburg, Germany; Mahmoud Aljurf, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia; Charles Craddock, Queen Elizabeth Hospital, Birmingham, United Kingdom; Jan J. Cornelissen, Erasmus University Medical Center, Rotterdam, the Netherlands; and Frederic Baron, University of Liège, Liège, Belgium. shouval@gmail.com.
  • Joshua A Fein
    University of Connecticut Medical Center, Farmington, CT, USA.
  • Bipin Savani
    Division of Hematology-Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Mohamad Mohty
    Roni Shouval, Hila Mishan-Shamay, Avichai Shimoni, and Arnon Nagler, The Chaim Sheba Medical Center, Tel-Hashomer; Roni Shouval, Ori Bondi, and Ron Unger, Bar-Ilan University, Ramat-Gan, Israel; Myriam Labopin, Norbert C. Gorin, Emmanuelle Polge, Arnon Nagler, and Mohamad Mohty, European Group for Blood and Marrow Transplantation; Myriam Labopin and Mohamad Mohty, Sorbonne Universités, Centre de Recherche (CDR) Saint-Antoine; Myriam Labopin and Mohamad Mohty, Institut National de la Santé et de la Recherche Médicale, CDR Saint-Antoine; Myriam Labopin and Mohamad Mohty, Assistance Publique-Hôpitaux de Paris, Hôpital Saint-Antoine, Paris, France; Fabio Ciceri, San Raffaele Scientific Institute, Milan; Andrea Bacigalupo, Ospedale San Martino, Genoa, Italy; Jordi Esteve, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain; Sebastian Giebel, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice, Poland; Christoph Schmid, Ludwig-Maximilians-University, Munich; Nicolaus Kroger, University Medical Center Hamburg Eppendorf, Hamburg, Germany; Mahmoud Aljurf, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia; Charles Craddock, Queen Elizabeth Hospital, Birmingham, United Kingdom; Jan J. Cornelissen, Erasmus University Medical Center, Rotterdam, the Netherlands; and Frederic Baron, University of Liège, Liège, Belgium.
  • Arnon Nagler
    Roni Shouval, Hila Mishan-Shamay, Avichai Shimoni, and Arnon Nagler, The Chaim Sheba Medical Center, Tel-Hashomer; Roni Shouval, Ori Bondi, and Ron Unger, Bar-Ilan University, Ramat-Gan, Israel; Myriam Labopin, Norbert C. Gorin, Emmanuelle Polge, Arnon Nagler, and Mohamad Mohty, European Group for Blood and Marrow Transplantation; Myriam Labopin and Mohamad Mohty, Sorbonne Universités, Centre de Recherche (CDR) Saint-Antoine; Myriam Labopin and Mohamad Mohty, Institut National de la Santé et de la Recherche Médicale, CDR Saint-Antoine; Myriam Labopin and Mohamad Mohty, Assistance Publique-Hôpitaux de Paris, Hôpital Saint-Antoine, Paris, France; Fabio Ciceri, San Raffaele Scientific Institute, Milan; Andrea Bacigalupo, Ospedale San Martino, Genoa, Italy; Jordi Esteve, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain; Sebastian Giebel, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice, Poland; Christoph Schmid, Ludwig-Maximilians-University, Munich; Nicolaus Kroger, University Medical Center Hamburg Eppendorf, Hamburg, Germany; Mahmoud Aljurf, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia; Charles Craddock, Queen Elizabeth Hospital, Birmingham, United Kingdom; Jan J. Cornelissen, Erasmus University Medical Center, Rotterdam, the Netherlands; and Frederic Baron, University of Liège, Liège, Belgium.

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