Diffusion Histology Imaging Combining Diffusion Basis Spectrum Imaging (DBSI) and Machine Learning Improves Detection and Classification of Glioblastoma Pathology.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research
Published Date: Jul 21, 2020

Abstract

PURPOSE: Glioblastoma (GBM) is one of the deadliest cancers with no cure. While conventional MRI has been widely adopted to examine GBM clinically, accurate neuroimaging assessment of tumor histopathology for improved diagnosis, surgical planning, and treatment evaluation remains an unmet need in the clinical management of GBMs.

Authors

  • Zezhong Ye
    Artificial Intelligence in Medicine (AIM) Program, Harvard Medical School, Boston, Massachusetts, USA.
  • Richard L Price
    Department of Neurological Surgery, Washington University School of Medicine, St. Louis, Missouri.
  • Xiran Liu
    Department of Electrical & System Engineering, Washington University, St. Louis, Missouri.
  • Joshua Lin
    Keck School of Medicine, University of Southern California, Los Angeles, California, 90033.
  • Qingsong Yang
  • Peng Sun
    Department of Microelectronics, Nankai University, Tianjin, 300350, PR China.
  • Anthony T Wu
    Department of Biomedical Engineering, Washington University, St. Louis, Missouri, 63130.
  • Liang Wang
    Information Department, Dazhou Central Hospital, Dazhou 635000, China.
  • Rowland H Han
    Department of Neurological Surgery, Washington University School of Medicine, St. Louis, Missouri.
  • Chunyu Song
    Department of Biomedical Engineering, Washington University, St. Louis, Missouri.
  • Ruimeng Yang
    Department of Radiology, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, 510180, Guangdong, China.
  • Sam E Gary
    Medical Scientist Training Program, The University of Alabama at Birmingham, Birmingham, Alabama.
  • Diane D Mao
    Department of Neurological Surgery, Washington University School of Medicine, St. Louis, Missouri.
  • Michael Wallendorf
    Department of Biostatistics, Washington University School of Medicine, St. Louis, Missouri.
  • Jian L Campian
    Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri.
  • Jr-Shin Li
    Washington University in St. Louis, St. Louis, USA.
  • Sonika Dahiya
    Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri. alberthkim@wustl.edu sdahiya@wustl.edu.
  • Albert H Kim
    Department of Neurological Surgery, Washington University School of Medicine, St. Louis, Missouri. alberthkim@wustl.edu sdahiya@wustl.edu.
  • Sheng-Kwei Song
    Department of Radiology, Washington University School of Medicine, St. Louis, Missouri, 63110.

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