Classification of glomerular pathological findings using deep learning and nephrologist-AI collective intelligence approach.

Journal: International journal of medical informatics
Published Date:

Abstract

BACKGROUND: Automated classification of glomerular pathological findings is potentially beneficial in establishing an efficient and objective diagnosis in renal pathology. While previous studies have verified the artificial intelligence (AI) models for the classification of global sclerosis and glomerular cell proliferation, there are several other glomerular pathological findings required for diagnosis, and the comprehensive models for the classification of these major findings have not yet been reported. Whether the cooperation between these AI models and clinicians improves diagnostic performance also remains unknown. Here, we developed AI models to classify glomerular images for major findings required for pathological diagnosis and investigated whether those models could improve the diagnostic performance of nephrologists.

Authors

  • Eiichiro Uchino
    Department of Medical Intelligent Systems, Graduate School of Medicine, Kyoto University, Kyoto, Japan; Department of Nephrology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
  • Kanata Suzuki
    Fujitsu Laboratories LTD., Kawasaki, Japan.
  • Noriaki Sato
    Department of Nephrology, Graduate School of Medicine, Kyoto University, Kyoto, Japan; Department of Biomedical Data Intelligence, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
  • Ryosuke Kojima
    Department of Biomedical Data Intelligence, Kyoto University Graduate School of Medicine, Sakyo-ku, Kyoto, Kyoto, Japan.
  • Yoshinori Tamada
    Department of Medical Intelligent Systems, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
  • Shusuke Hiragi
    Graduate School of Informatics Kyoto University, Kyoto-City, Kyoto, Japan.
  • Hideki Yokoi
    Department of Nephrology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
  • Nobuhiro Yugami
    Fujitsu Laboratories LTD., Kawasaki, Japan.
  • Sachiko Minamiguchi
    Department of Diagnostic Pathology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
  • Hironori Haga
    Department of Diagnostic Pathology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
  • Motoko Yanagita
    Department of Nephrology, Graduate School of Medicine, Kyoto University, Kyoto, Japan; Institute for the Advanced Study of Human Biology (ASHBi), Kyoto University, Kyoto, Japan. Electronic address: motoy@kuhp.kyoto-u.ac.jp.
  • Yasushi Okuno
    Graduate School of Medicine, Kyoto University, Shogoin-kawaharacho, city/>Sakyo-ku Kyoto, 606-8507, Japan.