UniRule: a unified rule resource for automatic annotation in the UniProt Knowledgebase.

Journal: Bioinformatics (Oxford, England)
Published Date:

Abstract

MOTIVATION: The number of protein records in the UniProt Knowledgebase (UniProtKB: https://www.uniprot.org) continues to grow rapidly as a result of genome sequencing and the prediction of protein-coding genes. Providing functional annotation for these proteins presents a significant and continuing challenge.

Authors

  • Alistair MacDougall
    European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton, Cambridge, UK.
  • Vladimir Volynkin
    European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
  • Rabie Saidi
    European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton, Cambridge, UK.
  • Diego Poggioli
    European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton, Cambridge, UK.
  • Hermann Zellner
    European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
  • Emma Hatton-Ellis
    European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
  • Vishal Joshi
    European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
  • Claire O'Donovan
    European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
  • Sandra Orchard
    Department of Ecology and Evolution, University of Lausanne, 1015 Lausanne, Switzerland, SIB Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland, Department of Microbiology and Immunology and Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore MD, USA, SIB Swiss Institute of Bioinformatics, 1 Rue Michel Servet, 1211 Geneva, Switzerland, Department of Medicine and Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore MD, USA, Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA 94158, USA, School of Information, University of South Florida, Tampa, FL, 33647, USA, Genomics Division, Lawrence Berkeley National Lab, 1 Cyclotron Rd., Berkeley, 94720 CA USA, European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK, Swiss-Prot Group, SIB Swiss Institute of Bioinformatics, Centre Medical Universitaire, Geneva, Switzerland, ETH Zurich, Department of Computer Science, Universitätstr. 19, 8092 Zürich, Switzerland, SIB Swiss Institute of Bioinformatics, Universitätstr. 6, 8092 Zürich, Switzerland and University College London, Gower St, London WC1E 6BT, UK.
  • Andrea H Auchincloss
    Swiss-Prot group, SIB Swiss Institute of Bioinformatics, CMU, University of Geneva Medical School, 1211 Geneva, Switzerland. Andrea.Auchincloss@sib.swiss.
  • Delphine Baratin
    SIB Swiss Institute of Bioinformatics, Centre Medical Universitaire, CH-1211 Geneva 4, Switzerland.
  • Jerven Bolleman
    SIB Swiss Institute of Bioinformatics, Centre Medical Universitaire, CH-1211 Geneva 4, Switzerland.
  • Elisabeth Coudert
    SIB Swiss Institute of Bioinformatics, Centre Medical Universitaire, CH-1211 Geneva 4, Switzerland.
  • Edouard de Castro
    Swiss-Prot group, SIB Swiss Institute of Bioinformatics, CMU, University of Geneva Medical School, 1211 Geneva, Switzerland. edouard.decastro@sib.swiss.
  • Chantal Hulo
    Swiss-Prot group, SIB Swiss Institute of Bioinformatics, CMU, University of Geneva Medical School, 1211 Geneva, Switzerland. Chantal.Hulo@sib.swiss.
  • Patrick Masson
    Swiss-Prot group, SIB Swiss Institute of Bioinformatics, CMU, University of Geneva Medical School, 1211 Geneva, Switzerland. Patrick.Masson@sib.swiss.
  • Ivo Pedruzzi
    SIB Swiss Institute of Bioinformatics, Centre Medical Universitaire, CH-1211 Geneva 4, Switzerland.
  • Catherine Rivoire
    SIB Swiss Institute of Bioinformatics, Centre Medical Universitaire, CH-1211 Geneva 4, Switzerland.
  • Cecilia Arighi
    Center for Bioinformatics and Computational Biology, University of Delaware, Newark, Delaware, United States of America.
  • Qinghua Wang
  • Chuming Chen
    Protein Information Resource, University of Delaware, Newark, DE 19711, USA.
  • Hongzhan Huang
    Center for Bioinformatics and Computational Biology, University of Delaware, Newark, DE 19711, USA.
  • John Garavelli
    Protein Information Resource, University of Delaware, Newark, DE 19711, USA.
  • C R Vinayaka
    Protein Information Resource, Georgetown University Medical Center, Washington, DC 20007, USA.
  • Lai-Su Yeh
    Protein Information Resource, Georgetown University Medical Center, Washington, DC 20007, USA.
  • Darren A Natale
    Protein Information Resource, Department of Biochemistry and Molecular & Cellular Biology, Georgetown University Medical Center, Washington, D. C., United States of America.
  • Kati Laiho
    Protein Information Resource, Georgetown University Medical Center, Washington, DC 20007, USA.
  • Maria-Jesus Martin
    European Bioinformatics Institute (EMBL-EBI), European Molecular Biology Laboratory, Wellcome Genome Campus, Hinxton, Cambridge, UK.
  • Alexandre Renaux
    European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
  • Klemens Pichler
    European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK.