Exploring a Structural Basis for Delayed Rod-Mediated Dark Adaptation in Age-Related Macular Degeneration Via Deep Learning.

Journal: Translational vision science & technology
Published Date: Dec 1, 2020

Abstract

PURPOSE: Delayed rod-mediated dark adaptation (RMDA) is a functional biomarker for incipient age-related macular degeneration (AMD). We used anatomically restricted spectral domain optical coherence tomography (SD-OCT) imaging data to localize de novo imaging features associated with and to test hypotheses about delayed RMDA.

Authors

  • Aaron Y Lee
    Department of Ophthalmology, University of Washington, Seattle, Washington.
  • Cecilia S Lee
    Department of Ophthalmology, University of Washington, Seattle, Washington, USA.
  • Marian S Blazes
    Department of Ophthalmology, School of Medicine, University of Washington, Seattle, WA, USA.
  • Julia P Owen
    Department of Ophthalmology, University of Washington, Seattle, Washington.
  • Yelena Bagdasarova
    Department of Ophthalmology, School of Medicine, University of Washington, Seattle, WA, USA.
  • Yue Wu
    Key Laboratory of Luminescence and Real-Time Analytical Chemistry (Ministry of Education), College of Pharmaceutical Sciences, Southwest University, Chongqing 400716, China.
  • Theodore Spaide
    Department of Ophthalmology, School of Medicine, University of Washington, Seattle, WA, USA.
  • Ryan T Yanagihara
  • Yuka Kihara
    Department of Ophthalmology, University of Washington, Seattle.
  • Mark E Clark
    Department of Ophthalmology and Visual Sciences, School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
  • MiYoung Kwon
    Department of Ophthalmology and Visual Sciences, University of Alabama at Birmingham.
  • Cynthia Owsley
    Department of Ophthalmology and Visual Sciences, School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
  • Christine A Curcio
    Department of Ophthalmology and Visual Sciences, University of Alabama at Birmingham Heersink School of Medicine, Birmingham, Alabama.

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