Integration of NLP2FHIR Representation with Deep Learning Models for EHR Phenotyping: A Pilot Study on Obesity Datasets.

Journal: AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science
Published Date:

Abstract

HL7 Fast Healthcare Interoperability Resources (FHIR) is one of the current data standards for enabling electronic healthcare information exchange. Previous studies have shown that FHIR is capable of modeling both structured and unstructured data from electronic health records (EHRs). However, the capability of FHIR in enabling clinical data analytics has not been well investigated. The objective of the study is to demonstrate how FHIR-based representation of unstructured EHR data can be ported to deep learning models for text classification in clinical phenotyping. We leverage and extend the NLP2FHIR clinical data normalization pipeline and conduct a case study with two obesity datasets. We tested several deep learning-based text classifiers such as convolutional neural networks, gated recurrent unit, and text graph convolutional networks on both raw text and NLP2FHIR inputs. We found that the combination of NLP2FHIR input and text graph convolutional networks has the highest F1 score. Therefore, FHIR-based deep learning methods has the potential to be leveraged in supporting EHR phenotyping, making the phenotyping algorithms more portable across EHR systems and institutions.

Authors

  • Sijia Liu
    These authors contributed equally to this study and Dr. Li is now working at IBM; Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA; Department of Computer Science and Engineering, University at Buffalo, Buffalo, NY, USA.
  • Yuan Luo
    Department of Preventive Medicine, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA.
  • Daniel Stone
    Mayo Clinic, Rochester, MN.
  • Nansu Zong
    Health System Department of Biomedical Informatics, University of California, San Diego, La Jolla, California, USA.
  • Andrew Wen
    Department of Medical Informatics and Clinical Epidemiology, Oregon Health & Science University, Portland, OR, USA.
  • Yue Yu
    Department of Mathematics, Lehigh University, Bethlehem, PA, USA.
  • Luke V Rasmussen
    Northwestern University, Feinberg School of Medicine, Chicago, IL, USA.
  • Fei Wang
    Department of Population Health Sciences, Weill Cornell Medicine, Cornell University, New York, NY, United States.
  • Jyotishman Pathak
    Department of Population Health Sciences, Weill Cornell Medicine, New York, NY, USA.
  • Hongfang Liu
    Department of Artificial Intelligence & Informatics, Mayo Clinic, Rochester, MN, United States.
  • Guoqian Jiang
    Mayo Clinic College of Medicine, Rochester, MN, USA.