Blending Knowledge in Deep Recurrent Networks for Adverse Event Prediction at Hospital Discharge.

Journal: AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science
Published Date:

Abstract

Deep learning architectures have an extremely high-capacity for modeling complex data in a wide variety of domains. However, these architectures have been limited in their ability to support complex prediction problems using insurance claims data, such as readmission at 30 days, mainly due to data sparsity issue. Consequently, classical machine learning methods, especially those that embed domain knowledge in handcrafted features, are often on par with, and sometimes outperform, deep learning approaches. In this paper, we illustrate how the potential of deep learning can be achieved by blending domain knowledge within deep learning architectures to predict adverse events at hospital discharge, including readmissions. More specifically, we introduce a learning architecture that fuses a representation of patient data computed by a self-attention based recurrent neural network, with clinically relevant features. We conduct extensive experiments on a large claims dataset and show that the blended method outperforms the standard machine learning approaches.

Authors

  • Prithwish Chakraborty
    Center for Computational Health, IBM Research, Yorktown Heights, NY, USA.
  • James Codella
    IBM Research, USA.
  • Piyush Madan
    IBM Research, USA.
  • Ying Li
    School of Information Engineering, Chang'an University, Xi'an 710010, China.
  • Hu Huang
  • Yoonyoung Park
    4 IBM Corporation, IBM Research, Cambridge, Massachusetts.
  • Chao Yan
    School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China.
  • Ziqi Zhang
    Department of Electrical Engineering and Computer Science, Vanderbilt University, Nashville, Tennessee, USA.
  • Cheng Gao
    Dept. of Biomedical Informatics, School of Medicine, Vanderbilt University, Nashville, TN, USA.
  • Steve Nyemba
    Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
  • Xu Min
  • Sanjib Basak
    IBM Watson Health, USA.
  • Mohamed Ghalwash
    Center for Computational Health, IBM Research, Yorktown Heights, NY, USA.
  • Zach Shahn
    MIT-IBM Watson AI Lab, Cambridge, MA, USA.
  • Parthasararathy Suryanarayanan
    IBM Research, USA.
  • Italo Buleje
    IBM Research, USA.
  • Shannon Harrer
    IBM Watson Health, USA.
  • Sarah Miller
    IBM Research, USA.
  • Amol Rajmane
    IBM Watson Health, USA.
  • Colin Walsh
    Vanderbilt University, Nashville, TN, USA.
  • Jonathan Wanderer
    Vanderbilt University, Nashville, TN, USA.
  • Gigi Yuen Reed
    IBM Watson Health, USA.
  • Kenney Ng
    Center for Computational Health, IBM Research, Yorktown Heights, NY, USA.
  • Daby Sow
    Center for Computational Health, IBM Research, Yorktown Heights, NY, USA.
  • Bradley A Malin
    Vanderbilt University, Nashville, TN.