Hybrid manifold-deep convolutional neural network for sleep staging.

Journal: Methods (San Diego, Calif.)
Published Date:

Abstract

Analysis of electroencephalogram (EEG) is a crucial diagnostic criterion for many sleep disorders, of which sleep staging is an important component. Manual stage classification is a labor-intensive process and usually suffered from many subjective factors. Recently, more and more computer-aided techniques have been applied to this task, among which deep convolutional neural network has been performing well as an effective automatic classification model. Despite some comprehensive models have been developed to improve classification results, the accuracy for clinical applications has not been reached due to the lack of sufficient labeled data and the limitation of extracting latent discriminative EEG features. Therefore, we propose a novel hybrid manifold-deep convolutional neural network with hyperbolic attention. To overcome the shortage of labeled data, we update the semi-supervised training scheme as an optimal solution. In order to extract the latent feature representation, we introduce the manifold learning module and the hyperbolic module to extract more discriminative information. Eight subjects from the public dataset are utilized to evaluate our pipeline, and the model achieved 89% accuracy, 70% precision, 80% sensitivity, 72% f1-score and kappa coefficient of 78%, respectively. The proposed model demonstrates powerful ability in extracting feature representation and achieves promising results by using semi-supervised training scheme. Therefore, our approach shows strong potential for future clinical development.

Authors

  • Chuanhao Zhang
    Shandong Key Laboratory of Medical Physics and Image Processing, Shandong Institute of Industrial Technology for Health Sciences and Precision Medicine, School of Physics and Electronics, Shandong Normal University, Jinan, Shandong, 250358, China.
  • Sen Liu
    Automotive Data Center, China Automotive Technology & Research, Tianjin, 300300, China.
  • Fang Han
    Department of Respiratory Medicine and Intensive Care Unit.Peking University People's Hospital, Beijing 100044, China; Email: hanfangl@hotmail.com.
  • Zedong Nie
    Center for Medical Robotics and Minimally Invasive Surgical Devices, Shenzhen Institutes of Advance Technology, Chinese Academy of Sciences, Shenzhen, China.
  • Benny Lo
  • Yuan Zhang
    Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.