Accurate diagnosis of colorectal cancer based on histopathology images using artificial intelligence.

Journal: BMC medicine
Published Date:

Abstract

BACKGROUND: Accurate and robust pathological image analysis for colorectal cancer (CRC) diagnosis is time-consuming and knowledge-intensive, but is essential for CRC patients' treatment. The current heavy workload of pathologists in clinics/hospitals may easily lead to unconscious misdiagnosis of CRC based on daily image analyses.

Authors

  • K S Wang
    Department of Pathology, Xiangya Hospital, Central South University, Changsha, 410078, Hunan, China.
  • G Yu
    Delft University of Technology, Delft, 2628CN / 2600GA, Netherlands.
  • C Xu
    Department of Biostatistics and Epidemiology, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA.
  • X H Meng
    Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Changsha, 410081, Hunan, China.
  • J Zhou
    Department of Epidemiology and Health Statistics,Guangdong Pharmaceutical University,Guangzhou,China.
  • C Zheng
    Department of Pathology, Xiangya Hospital, Central South University, Changsha, 410078, Hunan, China.
  • Z Deng
    Department of Pathology, Xiangya Hospital, Central South University, Changsha, 410078, Hunan, China.
  • L Shang
    Department of Pathology, Xiangya Hospital, Central South University, Changsha, 410078, Hunan, China.
  • R Liu
    Department of Pathology, Xiangya Hospital, Central South University, Changsha, 410078, Hunan, China.
  • S Su
    Department of Pathology, Xiangya Hospital, Central South University, Changsha, 410078, Hunan, China.
  • X Zhou
    Department of Pathology, Xiangya Hospital, Central South University, Changsha, 410078, Hunan, China.
  • Q Li
    Department of Pathology, Xiangya Hospital, Central South University, Changsha, 410078, Hunan, China.
  • J Li
    Department of Pulmonary and Critical Care Medicine, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China.
  • J Wang
    Joint Laboratory of Modern Agricultural Technology International Cooperation; Key Laboratory of Animal Production, Product Quality, and Security; College of Animal Science and Technology, Jilin Agricultural University, Changchun, China. moa4short@outlook.com.
  • K Ma
    Department of Pathology, School of Basic Medical Science, Central South University, Changsha, 410013, Hunan, China.
  • J Qi
    Department of Pathology, School of Basic Medical Science, Central South University, Changsha, 410013, Hunan, China.
  • Z Hu
    Department of Pathology, School of Basic Medical Science, Central South University, Changsha, 410013, Hunan, China.
  • P Tang
    Department of Pathology, School of Basic Medical Science, Central South University, Changsha, 410013, Hunan, China.
  • J Deng
    Department of Deming Department of Medicine, Tulane Center of Biomedical Informatics and Genomics, Tulane University School of Medicine, 1440 Canal Street, Suite 1610, New Orleans, LA, 70112, USA.
  • X Qiu
    Centers of System Biology, Data Information and Reproductive Health, School of Basic Medical Science, School of Basic Medical Science, Central South University, Changsha, 410008, Hunan, China.
  • B Y Li
    Centers of System Biology, Data Information and Reproductive Health, School of Basic Medical Science, School of Basic Medical Science, Central South University, Changsha, 410008, Hunan, China.
  • W D Shen
    School of Basic Medicine and Biological Sciences, Soochow University, Suzhou, Jiangsu 215123, PR China; National Engineering Laboratory for Modern Silk, Soochow University, Suzhou, Jiangsu 215123, PR China.
  • R P Quan
    Centers of System Biology, Data Information and Reproductive Health, School of Basic Medical Science, School of Basic Medical Science, Central South University, Changsha, 410008, Hunan, China.
  • J T Yang
    Centers of System Biology, Data Information and Reproductive Health, School of Basic Medical Science, School of Basic Medical Science, Central South University, Changsha, 410008, Hunan, China.
  • L Y Huang
    Centers of System Biology, Data Information and Reproductive Health, School of Basic Medical Science, School of Basic Medical Science, Central South University, Changsha, 410008, Hunan, China.
  • Y Xiao
    Centers of System Biology, Data Information and Reproductive Health, School of Basic Medical Science, School of Basic Medical Science, Central South University, Changsha, 410008, Hunan, China.
  • Z C Yang
    Department of Pharmacology, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, 410078, Hunan, China.
  • Z Li
    Department of Pediatrics, Jinhua Maternal and Child Health Hospital, Jinhua, 321000, China.
  • S C Wang
    College of Information Science and Engineering, Hunan Normal University, Changsha, 410081, Hunan, China.
  • H Ren
    Department of Pathology, Gongli Hospital, Second Military Medical University, Shanghai, 200135, China.
  • C Liang
    Pathological Laboratory of Adicon Medical Laboratory Co., Ltd, Hangzhou, 310023, Zhejiang, China.
  • W Guo
    Department of Pathology, First Affiliated Hospital of Hunan Normal University, The People's Hospital of Hunan Province, Changsha, 410005, Hunan, China.
  • Y Li
  • H Xiao
    Department of Pathology, the Third Xiangya Hospital, Central South University, Changsha, 410013, Hunan, China.
  • Y Gu
    Department of Pathology, the Third Xiangya Hospital, Central South University, Changsha, 410013, Hunan, China.
  • J P Yun
    Department of Pathology, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, China.
  • D Huang
    Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, 200032, China.
  • Z Song
    Department of Pathology, Chinese PLA General Hospital, Beijing, 100853, China.
  • X Fan
    Department of Pathology, Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School, Nanjing, 210008, China.
  • L Chen
    College of Computing, Georgia Institute of Technology, Atlanta, GA, USA.
  • X Yan
    Institute of Pathology and southwest cancer center, Southwest Hospital, Third Military Medical University, Chongqing, 400038, China.
  • Z C Huang
    Department of Biomedical Engineering, School of Basic Medical Science, Central South University, Changsha, 410013, Hunan, China.
  • J Huang
    Guangxi Key Laboratory of AIDS Prevention and Treatment & Guangxi Universities Key Laboratory of Prevention and Control of Highly Prevalent Disease, School of Public Health, Guangxi Medical University,Nanning 530021, Guangxi,China.
  • J Luttrell
    School of Computing Sciences and Computer Engineering, University of Southern Mississippi, Hattiesburg, MS, 39406, USA.
  • C Y Zhang
    School of Computing Sciences and Computer Engineering, University of Southern Mississippi, Hattiesburg, MS, 39406, USA.
  • W Zhou
    College of Computing, Michigan Technological University, Houghton, MI, 49931, USA.
  • K Zhang
    Department of Computer Science, Bioinformatics Facility of Xavier NIH RCMI Cancer Research Center, Xavier University of Louisiana, New Orleans, LA, 70125, USA.
  • C Yi
    Department of Pathology, Ochsner Medical Center, New Orleans, LA, 70121, USA.
  • C Wu
    Department of Statistics, Florida State University, Tallahassee, FL, 32306, USA.
  • H Shen
    Department of Deming Department of Medicine, Tulane Center of Biomedical Informatics and Genomics, Tulane University School of Medicine, 1440 Canal Street, Suite 1610, New Orleans, LA, 70112, USA.
  • Y P Wang
    Department of Deming Department of Medicine, Tulane Center of Biomedical Informatics and Genomics, Tulane University School of Medicine, 1440 Canal Street, Suite 1610, New Orleans, LA, 70112, USA.
  • H M Xiao
    Centers of System Biology, Data Information and Reproductive Health, School of Basic Medical Science, School of Basic Medical Science, Central South University, Changsha, 410008, Hunan, China. hmxiao@csu.edu.cn.
  • H W Deng
    Department of Deming Department of Medicine, Tulane Center of Biomedical Informatics and Genomics, Tulane University School of Medicine, 1440 Canal Street, Suite 1610, New Orleans, LA, 70112, USA. hdeng2@tulane.edu.