Antitubercular metabolites from the marine-derived fungus strain MF029.

Journal: Natural product research
PMID: 34414849

Abstract

During the systematic screening of bioactive compounds from our marine natural product library, crude extract of the marine-derived fungus strain MF029 exhibited moderate bioactivities against , S, methicillin-resistant , and bacillus Calmette-Guérin (BCG). Further chemical investigation resulted in the identification of two new compounds, chaetominine A () and sphingofungin I (), together with four known compounds, emodin (), chaetominine (), sphingofungin D () and trypacidin (). Trypacidin displayed potential antitubercular activity with MIC value of 1.25 μg/mL.

Authors

  • Zhijun Song
    CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
  • Yu Liu
    Research Center of Information Technology, Beijing Academy of Agriculture and Forestry Science, Beijing, China.
  • Jieyu Gao
    CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
  • Jiansen Hu
    CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
  • Hongtao He
    CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
  • Shengwang Dai
    CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
  • Luoqiang Wang
    CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
  • Huanqin Dai
    CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
  • Lixin Zhang
    State Key Laboratory of Bioreactor Engineering, East China University of Science of Technology, Shanghai, China.
  • Fuhang Song
    CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.

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