CATH functional families predict functional sites in proteins.

Journal: Bioinformatics (Oxford, England)
Published Date: May 23, 2021

Abstract

MOTIVATION: Identification of functional sites in proteins is essential for functional characterization, variant interpretation and drug design. Several methods are available for predicting either a generic functional site, or specific types of functional site. Here, we present FunSite, a machine learning predictor that identifies catalytic, ligand-binding and protein-protein interaction functional sites using features derived from protein sequence and structure, and evolutionary data from CATH functional families (FunFams).

Authors

  • Sayoni Das
    PrecisionLife Ltd., Long Hanborough, OX29 8LJ Oxford, UK.
  • Harry M Scholes
    Institute of Structural and Molecular Biology, University College London, WC1E 6BT, London, UK.
  • Neeladri Sen
    Institute of Structural and Molecular Biology, University College London, WC1E 6BT, London, UK.
  • Christine Orengo
    Institute of Structural and Molecular Biology, University College London, London, UK. c.orengo@ucl.ac.uk.

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