Deep Feature Representations for Variable-Sized Regions of Interest in Breast Histopathology.

Journal: IEEE journal of biomedical and health informatics
Published Date:

Abstract

OBJECTIVE: Modeling variable-sized regions of interest (ROIs) in whole slide images using deep convolutional networks is a challenging task, as these networks typically require fixed-sized inputs that should contain sufficient structural and contextual information for classification. We propose a deep feature extraction framework that builds an ROI-level feature representation via weighted aggregation of the representations of variable numbers of fixed-sized patches sampled from nuclei-dense regions in breast histopathology images.

Authors

  • Caner Mercan
  • Bulut Aygunes
  • Selim Aksoy
  • Ezgi Mercan
    Paul G. Allen School of Computer Science and Engineering, University of Washington, Seattle.
  • Linda G Shapiro
    Paul G. Allen School of Computer Science and Engineering, University of Washington, Seattle.
  • Donald L Weaver
    Department of Pathology, University of Vermont, Burlington, VT, USA.
  • Joann G Elmore
    Department of Medicine, University of Washington School of Medicine, Seattle.