Single-cell classification using graph convolutional networks.

Journal: BMC bioinformatics
Published Date:

Abstract

BACKGROUND: Analyzing single-cell RNA sequencing (scRNAseq) data plays an important role in understanding the intrinsic and extrinsic cellular processes in biological and biomedical research. One significant effort in this area is the identification of cell types. With the availability of a huge amount of single cell sequencing data and discovering more and more cell types, classifying cells into known cell types has become a priority nowadays. Several methods have been introduced to classify cells utilizing gene expression data. However, incorporating biological gene interaction networks has been proved valuable in cell classification procedures.

Authors

  • Tianyu Wang
    State Key Laboratory of Mechanical System and Vibration, Shanghai Jiao Tong University; University of Michigan-Shanghai Jiao Tong University Joint Institute, Shanghai Jiao Tong University.
  • Jun Bai
    Department of Hematology, Gansu Provincial Key Laboratory of Hematology , Lanzhou University Second Hospital , Lanzhou 730000 , China.
  • Sheida Nabavi
    Department of Computer Science and Engineering, University of Connecticut, Storrs, 06269, CT, USA.