AIMC Topic: Gene Regulatory Networks

Clear Filters Showing 1 to 10 of 730 articles

Exploration of autophagy-associated genes and potential molecular mechanisms in type 1 diabetes and osteoporosis.

Scientific reports Aug 11, 2025
The co-occurrence of osteoporosis (OP) and type 1 diabetes mellitus (T1DM) represents a clinically significant comorbidity pattern, characterized by skeletal fragility and insulin deficiency. While epidemiological links exist, their shared molecular ...
Humans Diabetes Mellitus, Type 1 MicroRNAs Autophagy Gene Expression Regulation Osteoporosis Gene Expression Profiling Gene Regulatory Networks
View on PubMed DOI

Screening, identification, and experimental validation of SUMOylation biomarkers in Parkinson's disease.

Hereditas Aug 8, 2025
BACKGROUND: Parkinson's disease (PD) is a common neurodegenerative disorder. The role of protein post-translational modifications (PTMs), especially small ubiquitin-like modifier (SUMO) conjugation (SUMOylation), in PD pathogenesis remains unclear. T...
Ubiquitins Small Ubiquitin-Related Modifier Proteins Gene Regulatory Networks Parkinson Disease Biomarkers Humans Sumoylation Gene Expression Profiling
View on PubMed DOI

Identification and validation of hub genes related to neutrophil extracellular traps-mediated cell damage and immune recruitment during abdominal aortic aneurysm.

Scientific reports Aug 7, 2025
Previous research has shown that the formation of Neutrophil Extracellular Traps (NETs), mediated by neutrophils, leads to an increase in inflammatory cell response and cellular tissue damage during Abdominal Aortic Aneurysm (AAA). Building on this f...
Neutrophils Aortic Aneurysm, Abdominal Humans Gene Expression Profiling Computational Biology Extracellular Traps Transcriptome Gene Regulatory Networks
View on PubMed DOI

Network-based approach identifies key genes associated with tumor heterogeneity in HPV positive and negative head and neck cancer patients.

Scientific reports Aug 7, 2025
Head and Neck Squamous Cell Carcinoma (HNSCC) is the seventh most prevalent cancer worldwide and is classified as human papillomavirus (HPV) positive or negative. Substantial heterogeneity has been observed in the two groups, posing a significant cli...
Biomarkers, Tumor Gene Expression Profiling Gene Regulatory Networks Humans Squamous Cell Carcinoma of Head and Neck Head and Neck Neoplasms Gene Ontology Papillomaviridae Computational Biology Papillomavirus Infections Gene Expression Regulation, Neoplastic
View on PubMed DOI

Identification and experimental validation of mitochondrial and endoplasmic reticulum stress related gene in diabetic nephropathy.

Scientific reports Aug 7, 2025
Diabetic nephropathy (DN) is a kidney disease. Mitochondrial and endoplasmic reticulum stress (ERS) significantly contribute to diabetic nephropathy (DN), although the precise mechanisms involved have not yet been fully understood. The objective of t...
Mitochondria Gene Regulatory Networks Gene Expression Regulation Diabetic Nephropathies Endoplasmic Reticulum Stress Voltage-Dependent Anion Channel 1 Databases, Genetic Humans Gene Expression Profiling ROC Curve
View on PubMed DOI

Identifying ferroptosis-related genes in lung adenocarcinoma using random walk with restart in the PPI network.

Scientific reports Aug 6, 2025
Lung adenocarcinoma (LUAD), the most common non-small cell lung cancer subtype, often presents with subtle early symptoms leading to delayed diagnosis. Ferroptosis, a cell death process associated with iron metabolism dysregulation, has been linked t...
Humans Gene Expression Regulation, Neoplastic Ferroptosis Protein Interaction Maps Adenocarcinoma of Lung Algorithms Gene Regulatory Networks Tumor Microenvironment X-Box Binding Protein 1 Lung Neoplasms Gene Expression Profiling
View on PubMed DOI

In-depth bioinformatics analysis uncovers the crosstalk genes and immune interactions among diagnostic markers linked to natural killer cells in patients with cirrhosis and sepsis.

Clinical and experimental medicine Aug 6, 2025
Patients with cirrhosis face an elevated risk of developing sepsis, leading to an escalating mortality rate. This study focuses on the link between natural killer (NK) cells, cirrhosis, and sepsis. Our goal is to identify NK cell-related genes that c...
Killer Cells, Natural Computational Biology Biomarkers Liver Cirrhosis Gene Expression Profiling Databases, Genetic Humans Sepsis ROC Curve Gene Regulatory Networks
View on PubMed DOI

Bioinformatics analysis of Rho-signal transduction genes in postmenopausal osteoporosis and periodontitis.

Scientific reports Aug 5, 2025
Postmenopausal osteoporosis (PMOP) increases the risk of periodontitis (PD), yet the shared mechanisms remain unclear. Rho-signal transduction genes may play a role due to their involvement in bone remodeling. This study aimed to explore Rho-related ...
Signal Transduction Disease Models, Animal RNA, Long Noncoding c-Mer Tyrosine Kinase Periodontitis Osteoporosis, Postmenopausal Humans Gene Regulatory Networks Biomarkers Mice Female Computational Biology Animals Gene Expression Profiling
View on PubMed DOI

Identification of DNA damage response and crotonylation-related biomarkers for lung adenocarcinoma via machine learning and WGCNA.

Clinical and experimental medicine Jul 30, 2025
DNA damage response (DDR) and crotonylation occur frequently in lung adenocarcinoma (LUAD), but their relationship is yet to be elucidated. RNA sequencing data from LUAD patients in GSE27262 and GSE140797 datasets were obtained. DDR-crotonylation-rel...
Biomarkers, Tumor Gene Expression Profiling Gene Regulatory Networks Humans DNA Damage Machine Learning Lung Neoplasms Adenocarcinoma of Lung Computational Biology Gene Expression Regulation, Neoplastic
View on PubMed DOI

Interpretable graph Kolmogorov-Arnold networks for multi-cancer classification and biomarker identification using multi-omics data.

Scientific reports Jul 29, 2025
The integration of heterogeneous multi-omics datasets at a systems level remains a central challenge for developing analytical and computational models in precision cancer diagnostics. This paper introduces Multi-Omics Graph Kolmogorov-Arnold Network...
MicroRNAs Protein Interaction Maps Neoplasms Humans Multiomics Gene Expression Profiling Gene Regulatory Networks Algorithms Gene Expression Regulation, Neoplastic Deep Learning Computational Biology Biomarkers, Tumor DNA Methylation
View on PubMed DOI
Popular Topics
Recent Journals