ChemFLuo: a web-server for structure analysis and identification of fluorescent compounds.

Journal: Briefings in bioinformatics
Published Date: Jul 20, 2021

Abstract

BACKGROUND: Fluorescent detection methods are indispensable tools for chemical biology. However, the frequent appearance of potential fluorescent compound has greatly interfered with the recognition of compounds with genuine activity. Such fluorescence interference is especially difficult to identify as it is reproducible and possesses concentration-dependent characteristic. Therefore, the development of a credible screening tool to detect fluorescent compounds from chemical libraries is urgently needed in early stages of drug discovery.

Authors

  • Zi-Yi Yang
  • Jie Dong
    Department of Urology, Eastern Theater Command General Hospital, Nanjing，Jiangsu 210002, Chinia.
  • Zhi-Jiang Yang
    Xiangya School of Pharmaceutical Sciences , Central South University , Changsha 410013 , Hunan , P. R. China.
  • Mingzhu Yin
    Department of Dermatology, Hunan Engineering Research Center of Skin Health and Disease, Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, P.R. China.
  • Hong-Li Jiang
    Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, 410003, P. R. China.
  • Ai-Ping Lu
    Lab of Brain and Gut Research, School of Chinese Medicine, Hong Kong Baptist University, 7 Baptist University Road, Hong Kong, People's Republic of China.
  • Xiang Chen
    Yangtze Delta Region Institute (Huzhou), University of Electronic Science and Technology of China, Huzhou, Zhejiang, China.
  • Ting-Jun Hou
    Hangzhou Institute of Innovative Medicine, College of Pharmaceutical Sciences , Zhejiang University , Hangzhou 310058 , Zhejiang , P. R. China.
  • Dong-Sheng Cao
    Xiangya School of Pharmaceutical Sciences , Central South University , Changsha 410013 , Hunan , P. R. China.

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