Contour Transformer Network for One-Shot Segmentation of Anatomical Structures.

Journal: IEEE transactions on medical imaging
Published Date:

Abstract

Accurate segmentation of anatomical structures is vital for medical image analysis. The state-of-the-art accuracy is typically achieved by supervised learning methods, where gathering the requisite expert-labeled image annotations in a scalable manner remains a main obstacle. Therefore, annotation-efficient methods that permit to produce accurate anatomical structure segmentation are highly desirable. In this work, we present Contour Transformer Network (CTN), a one-shot anatomy segmentation method with a naturally built-in human-in-the-loop mechanism. We formulate anatomy segmentation as a contour evolution process and model the evolution behavior by graph convolutional networks (GCNs). Training the CTN model requires only one labeled image exemplar and leverages additional unlabeled data through newly introduced loss functions that measure the global shape and appearance consistency of contours. On segmentation tasks of four different anatomies, we demonstrate that our one-shot learning method significantly outperforms non-learning-based methods and performs competitively to the state-of-the-art fully supervised deep learning methods. With minimal human-in-the-loop editing feedback, the segmentation performance can be further improved to surpass the fully supervised methods.

Authors

  • Yuhang Lu
    School of Public Health, Chengdu Medical College, Chengdu 610500, China.
  • Kang Zheng
    PAII Inc., Bethesda, MD, USA.
  • Weijian Li
    PAII Inc., Bethesda, MD, USA.
  • Yirui Wang
    The College of Information Sciences and Technology, Donghua University, Shanghai 201620, China.
  • Adam P Harrison
    Imaging Biomarkers and Computer-Aided Diagnosis Laboratory, Clinical Image Processing Service, Radiology and Imaging Sciences Department, National Institutes of Health Clinical Center, Bethesda, MD 20892-1182, USA.
  • Chihung Lin
    Center for Artificial Intelligence in Medicine, Chang Gung Memorial Hospital, Taipei, Taiwan.
  • Song Wang
    Key Laboratory of Precision and Intelligent Chemistry, School of Chemistry and Materials Science, University of Science and Technology of China, China.
  • Jing Xiao
    Xiyuan Hospital, China Academy of Chinese Medical Sciences(CACMS), Beijing, China.
  • Le Lu
  • Chang-Fu Kuo
    Department of Rheumatology, Allergy, and Immunology, Chang Gung Memorial Hospital, Taipei, Taiwan, ROC.
  • Shun Miao
    Siemens Healthineers, Medical Imaging Technologies, Princeton, NJ, USA.