Protein-protein interaction prediction based on ordinal regression and recurrent convolutional neural networks.
Journal:
BMC bioinformatics
Published Date:
Oct 8, 2021
Abstract
BACKGROUND: Protein protein interactions (PPIs) are essential to most of the biological processes. The prediction of PPIs is beneficial to the understanding of protein functions and thus is helpful to pathological analysis, disease diagnosis and drug design etc. As the amount of protein data is growing fast in the post genomic era, high-throughput experimental methods are expensive and time-consuming for the prediction of PPIs. Thus, computational methods have attracted researcher's attention in recent years. A large number of computational methods have been proposed based on different protein sequence encoders.