SicknessMiner: a deep-learning-driven text-mining tool to abridge disease-disease associations.

Journal: BMC bioinformatics
Published Date:

Abstract

BACKGROUND: Blood cancers (BCs) are responsible for over 720 K yearly deaths worldwide. Their prevalence and mortality-rate uphold the relevance of research related to BCs. Despite the availability of different resources establishing Disease-Disease Associations (DDAs), the knowledge is scattered and not accessible in a straightforward way to the scientific community. Here, we propose SicknessMiner, a biomedical Text-Mining (TM) approach towards the centralization of DDAs. Our methodology encompasses Named Entity Recognition (NER) and Named Entity Normalization (NEN) steps, and the DDAs retrieved were compared to the DisGeNET resource for qualitative and quantitative comparison.

Authors

  • Nícia Rosário-Ferreira
    CQC - Coimbra Chemistry Center, Chemistry Department, Faculty of Science and Technology, University of Coimbra, 3004-535, Coimbra, Portugal. nicia.ferreira@student.uc.pt.
  • Victor Guimarães
    Department of Sciences, University of Porto, Porto, Portugal.
  • Vítor S Costa
    Department of Sciences, University of Porto, Porto, Portugal.
  • Irina S Moreira
    CNC-Center for Neuroscience and Cell Biology; Rua Larga, Faculdade de Medicina, Polo I, 1ºandar, Universidade de Coimbra, 3004-504 Coimbra, Portugal. irina.moreira@cnc.uc.pt.