GraphSynergy: a network-inspired deep learning model for anticancer drug combination prediction.

Journal: Journal of the American Medical Informatics Association : JAMIA
Published Date: Oct 12, 2021

Abstract

OBJECTIVE: To develop an end-to-end deep learning framework based on a protein-protein interaction (PPI) network to make synergistic anticancer drug combination predictions.

Authors

  • Jiannan Yang
    School of Data Science, City University of Hong Kong, Hong Kong, S.A.R. of China.
  • Zhongzhi Xu
    School of Public Health, Sun Yat-sen University, Guangzhou, China.
  • William Ka Kei Wu
    Department of Anaesthesia and Intensive Care, Chinese University of Hong Kong, Hong Kong, S.A.R. of China.
  • Qian Chu
    Department of Thoracic Oncology, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China.
  • Qingpeng Zhang
    Department of Pharmacology and Pharmacy, The University of Hong Kong, Hong Kong, Hong Kong SAR, China.

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