Deep learning analysis of electrocardiogram for risk prediction of drug-induced arrhythmias and diagnosis of long QT syndrome.

Journal: European heart journal
PMID: 34468739

Abstract

AIMS: Congenital long-QT syndromes (cLQTS) or drug-induced long-QT syndromes (diLQTS) can cause torsade de pointes (TdP), a life-threatening ventricular arrhythmia. The current strategy for the identification of drugs at the high risk of TdP relies on measuring the QT interval corrected for heart rate (QTc) on the electrocardiogram (ECG). However, QTc has a low positive predictive value.

Authors

  • Edi Prifti
    Integromics, Institute of Cardiometabolism and Nutrition, ICAN, Assistance Publique Hôpitaux de Paris, Pitié-Salpêtrière Hospital, Paris, 75013, France.
  • Ahmad Fall
    IRD, Sorbonne University, UMMISCO, 32 Avenue Henri Varagnat, Bondy 93143, France.
  • Giovanni Davogustto
    Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Alfredo Pulini
    IRD, Sorbonne University, UMMISCO, 32 Avenue Henri Varagnat, Bondy 93143, France.
  • Isabelle Denjoy
    CNMR Maladies Cardiaques Héréditaires Rares, Hôpital Bichat, Paris, France.
  • Christian Funck-Brentano
    Sorbonne Université, Clinical Investigation Center Paris-Est, CIC 1901, INSERM, AP-HP, Pitié-Salpêtrière University Hospital, Paris, France.
  • Yasmin Khan
    Banook Group, Nancy, France.
  • Alexandre Durand-Salmon
    Banook Group, Nancy, France.
  • Fabio Badilini
    Department of Physiological Nursing, University of California, San Francisco, CA, USA.
  • Quinn S Wells
    Department of Medicine, Vanderbilt University, Nashville, TN, 37232, USA.
  • Antoine Leenhardt
    CNMR Maladies Cardiaques Héréditaires Rares, Hôpital Bichat, Paris, France.
  • Jean-Daniel Zucker
    Integromics, Institute of Cardiometabolism and Nutrition, ICAN, Assistance Publique Hôpitaux de Paris, Pitié-Salpêtrière Hospital, Paris, 75013, France. jean-daniel.zucker@ird.fr.
  • Dan M Roden
    Vanderbilt University Medical Center, Nashville, TN, USA.
  • Fabrice Extramiana
    CNMR Maladies Cardiaques Héréditaires Rares, Hôpital Bichat, Paris, France.
  • Joe-Elie Salem
    Sorbonne Université, Clinical Investigation Center Paris-Est, CIC 1901, INSERM, AP-HP, Pitié-Salpêtrière University Hospital, Paris, France.

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