Determining the adjusted initial treatment dose of warfarin anticoagulant medicine using kernel-based support vector regression.

Journal: Computer methods and programs in biomedicine
PMID: 34963093

Abstract

BACKGROUND AND OBJECTIVE: A novel research field in bioinformatics is pharmacogenomics and the corresponding applications of artificial intelligence tools. Pharmacogenomics is the study of the relationship between genotype and responses to medical measures such as drug use. One of the most effective drugs is warfarin anticoagulant, but determining its initial treatment dose is challenging. Mistakes in the determination of the initial treatment dose can result directly in patient death.

Authors

  • Rouhollah Maghsoudi
    Department of Computer Engineering, Science and Research Branch,Islamic Azad University, Tehran, Iran.
  • Mitra Mirzarezaee
    Department of Computer Engineering, Science and Research branch, Islamic Azad University, Tehran, Iran.
  • Mehdi Sadeghi
    National Institute of Genetic Engineering and Biotechnology, Tehran, Iran.
  • Babak Nadjar-Araabi
    School of Electrical and Computer Eng, College of Eng, University of Tehran, Iran.

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