Structure-aware protein-protein interaction site prediction using deep graph convolutional network.
Journal:
Bioinformatics (Oxford, England)
Published Date:
Dec 22, 2021
Abstract
MOTIVATION: Protein-protein interactions (PPI) play crucial roles in many biological processes, and identifying PPI sites is an important step for mechanistic understanding of diseases and design of novel drugs. Since experimental approaches for PPI site identification are expensive and time-consuming, many computational methods have been developed as screening tools. However, these methods are mostly based on neighbored features in sequence, and thus limited to capture spatial information.