Precise estimation of residue relative solvent accessible area from Cα atom distance matrix using a deep learning method.

Journal: Bioinformatics (Oxford, England)
Published Date: Dec 22, 2021

Abstract

MOTIVATION: The solvent accessible surface is an essential structural property measure related to the protein structure and protein function. Relative solvent accessible area (RSA) is a standard measure to describe the degree of residue exposure in the protein surface or inside of protein. However, this computation will fail when the residues information is missing.

Authors

  • Jianzhao Gao
    School of Mathematical Sciences and LPMC, Nankai University, Tianjin, People's Republic of China.
  • Shuangjia Zheng
    Research Center for Drug Discovery, School of Pharmaceutical Sciences , Sun Yat-sen University , 132 East Circle at University City , Guangzhou 510006 , China.
  • Mengting Yao
    School of Mathematical Sciences and LPMC, Nankai University, Tianjin 300071, China.
  • Peikun Wu
    School of Mathematical Sciences and LPMC, Nankai University, Tianjin 300071, China.

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