Scoping review of the current landscape of AI-based applications in clinical trials.

Journal: Frontiers in public health
Published Date:

Abstract

BACKGROUND: Clinical trials are essential for bringing new drugs, technologies and procedures to the market and clinical practice. Considering the design and the four-phase development, only 10% of them complete the entire process, partly due to the increasing costs and complexity of clinical trials. This low completion rate has a huge negative impact in terms of population health, quality of care and health economics and sustainability. Automating some of the process' tasks with artificial intelligence (AI) tools could optimize some of the most burdensome ones, like patient selection, matching and enrollment; better patient selection could also reduce harmful treatment side effects. Although the pharmaceutical industry is embracing artificial AI tools, there is little evidence in the literature of their application in clinical trials.

Authors

  • Fidelia Cascini
    Section of Hygiene and Public Health, Department of Life Sciences and Public Health, Università Cattolica del Sacro Cuore, Rome, Italy.
  • Flavia Beccia
    Section of Hygiene and Public Health, Department of Life Sciences and Public Health, Università Cattolica del Sacro Cuore, Rome, Italy.
  • Francesco Andrea Causio
    Section of Hygiene and Public Health, Department of Life Sciences and Public Health, Università Cattolica del Sacro Cuore, Rome, Italy.
  • Andriy Melnyk
    Section of Hygiene, Department of Life Sciences and Public Health, Università Cattolica Del Sacro Cuore, Rome, Italy.
  • Andrea Zaino
    Section of Hygiene, Department of Life Sciences and Public Health, Università Cattolica Del Sacro Cuore, Rome, Italy.
  • Walter Ricciardi
    Section of Hygiene and Public Health, Department of Life Sciences and Public Health, Università Cattolica del Sacro Cuore, Rome, Italy.