DeepTrio: a ternary prediction system for protein-protein interaction using mask multiple parallel convolutional neural networks.

Journal: Bioinformatics (Oxford, England)
Published Date: Jan 12, 2022

Abstract

MOTIVATION: Protein-protein interaction (PPI), as a relative property, is determined by two binding proteins, which brings a great challenge to design an expert model with an unbiased learning architecture and a superior generalization performance. Additionally, few efforts have been made to allow PPI predictors to discriminate between relative properties and intrinsic properties.

Authors

  • Xiaotian Hu
    Department of Electrical Engineering, Columbia University, New York, New York, United States of America.
  • Cong Feng
    Department of Emergency, The First Medical Center to Chinese People's Liberation Army General Hospital, Beijing, China.
  • Yincong Zhou
    Department of Bioinformatics, College of Life Sciences, Zhejiang University, Hangzhou 310058, China.
  • Andrew Harrison
    Department of Anesthesiology, Mayo Clinic, Rochester, Minnesota, USA.
  • Ming Chen
    Department of Critical Care Medicine, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu, China.

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