EnsembleFam: towards more accurate protein family prediction in the twilight zone.
Journal:
BMC bioinformatics
Published Date:
Mar 14, 2022
Abstract
BACKGROUND: Current protein family modeling methods like profile Hidden Markov Model (pHMM), k-mer based methods, and deep learning-based methods do not provide very accurate protein function prediction for proteins in the twilight zone, due to low sequence similarity to reference proteins with known functions.