Discovery of moiety preference by Shapley value in protein kinase family using random forest models.

Journal: BMC bioinformatics
Published Date: Apr 15, 2022

Abstract

BACKGROUND: Human protein kinases play important roles in cancers, are highly co-regulated by kinase families rather than a single kinase, and complementarily regulate signaling pathways. Even though there are > 100,000 protein kinase inhibitors, only 67 kinase drugs are currently approved by the Food and Drug Administration (FDA).

Authors

  • Yu-Wei Huang
    Institute of Biomedical Engineering, National Yang Ming Chiao Tung University, Hsinchu, Taiwan.
  • Yen-Chao Hsu
    Institute of Bioinformatics and Systems Biology, National Yang Ming Chiao Tung University, Hsinchu, Taiwan.
  • Yi-Hsuan Chuang
    Institute of Bioinformatics and Systems Biology, National Yang Ming Chiao Tung University, Hsinchu, Taiwan.
  • Yun-Ti Chen
    Institute of Bioinformatics and Systems Biology, National Yang Ming Chiao Tung University, Hsinchu, 300, Taiwan.
  • Xiang-Yu Lin
    Institute of Bioinformatics and Systems Biology, National Yang Ming Chiao Tung University, Hsinchu, Taiwan.
  • You-Wei Fan
    Institute of Molecular Medicine and Bioengineering, National Yang Ming Chiao Tung University, Hsinchu, Taiwan.
  • Nikhil Pathak
    Institute of Bioinformatics and Systems Biology, National Yang Ming Chiao Tung University, Hsinchu, Taiwan.
  • Jinn-Moon Yang
    Institute of Bioinformatics and Systems Biology, National Chiao Tung University, Hsinchu 300, Taiwan.

Keywords

External Resources

Popular Topics
Recent Journals