EPI-Mind: Identifying Enhancer-Promoter Interactions Based on Transformer Mechanism.

Journal: Interdisciplinary sciences, computational life sciences
Published Date: Sep 1, 2022

Abstract

MOTIVATION: Enhancer-Promoter Interactions (EPIs) is an essential step in the gene regulation process. However, the detection of EPIs by traditional wet experimental techniques is time-consuming and expensive. Thus, computational methods would be very useful for understanding the mechanism of EPIs. A number of approaches have been proposed to address this problem. Nevertheless, there is room for exploration and improvement for the existing research methods.

Authors

  • Yu Ni
    College of Life Sciences, Northwest A&F University, Taicheng Road, Yangling, 712100, China.
  • Linqi Fan
    The 5th Paradigm Technology Co., Ltd, Yuanjiang Street, Shanghai, 200000, China.
  • Miao Wang
    Public Affairs Department, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
  • Ning Zhang
    Institute of Nuclear Agricultural Sciences, Zhejiang University, Hangzhou, 310058, China.
  • Yongchun Zuo
    The State key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, College of Life Sciences, Inner Mongolia University, Hohhot 010070, China.
  • Mingzhi Liao

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