Development and Validation of an Explainable Machine Learning Model for Major Complications After Cytoreductive Surgery.

Journal: JAMA network open
Published Date: May 2, 2022

Abstract

IMPORTANCE: Cytoreductive surgery (CRS) is one of the most complex operations in surgical oncology with significant morbidity, and improved risk prediction tools are critically needed. Machine learning models can potentially overcome the limitations of traditional multiple logistic regression (MLR) models and provide accurate risk estimates.

Authors

  • Huiyu Deng
    Department of Preventive Medicine, University of Southern California, 2001 N. Soto Street, MC-9234, Los Angeles, CA, 90089, USA.
  • Zahra Eftekhari
    City of Hope National Medical Center, Duarte, California.
  • Cameron Carlin
    The Laura P. and Leland K. Whittier Virtual Pediatric Intensive Care Unit, Children's Hospital Los Angeles, 4650 Sunset Blvd, Los Angeles, CA 90027, United States. Electronic address: cameronscarlin@gmail.com.
  • Jula Veerapong
    University of California at San Diego, San Diego.
  • Keith F Fournier
    MD Anderson Cancer Center, Houston, Texas.
  • Fabian M Johnston
    Johns Hopkins University, Baltimore, Maryland.
  • Sean P Dineen
    Moffitt Cancer Center, Tampa, Florida.
  • Benjamin D Powers
    Moffitt Cancer Center, Tampa, Florida.
  • Ryan Hendrix
    University of Massachusetts, Worcester, Massachusetts.
  • Laura A Lambert
    University of Utah, Salt Lake City.
  • Daniel E Abbott
    University of Wisconsin, Madison.
  • Kara Vande Walle
    Department of Surgery, University of Wisconsin, Madison, Wisconsin, USA.
  • Travis E Grotz
    Mayo Clinic, Rochester, Minnesota.
  • Sameer H Patel
    University of Cincinnati, Cincinnati, Ohio.
  • Callisia N Clarke
    Medical College of Wisconsin, Milwaukee, Wisconsin.
  • Charles A Staley
    Emory University, Atlanta, Georgia.
  • Sherif Abdel-Misih
    Ohio State University, Columbus.
  • Jordan M Cloyd
    Ohio State University, Columbus.
  • Byrne Lee
    Stanford University, Stanford, California.
  • Yuman Fong
    Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY.
  • Mustafa Raoof
    City of Hope National Medical Center, Duarte, California.

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