Scoring protein sequence alignments using deep learning.
Journal:
Bioinformatics (Oxford, England)
Published Date:
May 26, 2022
Abstract
MOTIVATION: A high-quality sequence alignment (SA) is the most important input feature for accurate protein structure prediction. For a protein sequence, there are many methods to generate a SA. However, when given a choice of more than one SA for a protein sequence, there are no methods to predict which SA may lead to more accurate models without actually building the models. In this work, we describe a method to predict the quality of a protein's SA.