Hyb4mC: a hybrid DNA2vec-based model for DNA N4-methylcytosine sites prediction.

Journal: BMC bioinformatics
Published Date: Jun 29, 2022

Abstract

BACKGROUND: DNA N4-methylcytosine is part of the restrictive modification system, which works by regulating some biological processes, for example, the initiation of DNA replication, mismatch repair and inactivation of transposon. However, using experimental methods to detect 4mC sites is time-consuming and expensive. Besides, considering the huge differences in the number of 4mC samples among different species, it is challenging to achieve a robust multi-species 4mC site prediction performance. Hence, it is of great significance to develop effective computational tools to identify 4mC sites.

Authors

  • Ying Liang
    Department of Therapeutic Radiology, Yale University, New Haven, CT, U.S.A.
  • Yanan Wu
    School of Physics and Optoelectronic Engineering, Ludong University, Yantai, Shandong 264025, China.
  • Zequn Zhang
    Aerospace Information Research Institute, Chinese Academy of Sciences, Beijing 100190, China.
  • Niannian Liu
    College of Computer and Information Engineering, Jiangxi Agricultural University, Nanchang, China.
  • Jun Peng
    a Department of Pharmacology, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha 410078, China.
  • Jianjun Tang
    College of Computer and Information Engineering, Jiangxi Agricultural University, Nanchang, China.

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