Pseudo-labeling generative adversarial networks for medical image classification.

Journal: Computers in biology and medicine
Published Date:

Abstract

Semi-supervised learning has become a popular technology in recent years. In this paper, we propose a novel semi-supervised medical image classification algorithm, called Pseudo-Labeling Generative Adversarial Networks (PLGAN), which only uses a small number of real images with few labels to generate fake images or mask images to enlarge the sample size of the labeled training set. First, we combine MixMatch to generate pseudo labels for the fake and unlabeled images to do the classification. Second, contrastive learning and self-attention mechanisms are introduced into PLGAN to exclude the influence of unimportant details. Third, the problem of mode collapse in contrastive learning is well addressed by cyclic consistency loss. Finally, we design global and local classifiers to complement each other with the key information needed for classification. The experimental results on four medical image datasets show that PLGAN can obtain relatively high learning performance by using few labeled and unlabeled data. For example, the classification accuracy of PLGAN is 11% higher than that of MixMatch with 100 labeled images and 1000 unlabeled images on the OCT dataset. In addition, we also conduct other experiments to verify the effectiveness of our algorithm.

Authors

  • Jiawei Mao
  • Xuesong Yin
    Department of Digital Media Technology, Hangzhou Dianzi University, Hangzhou, 310018, China. Electronic address: yinxs@hdu.edu.cn.
  • Guodao Zhang
    Department of Digital Media Technology, Hangzhou Dianzi University, Hangzhou, 310018, China. Electronic address: guodaozhang@zjut.edu.cn.
  • Bowen Chen
    Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Yuanqi Chang
    Department of Digital Media Technology, Hangzhou Dianzi University, Hangzhou, 310018, China. Electronic address: 211330020@hdu.edu.cn.
  • Weibin Chen
    Department of Thoracic Surgery, Zhongshan Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian, China.
  • Jieyue Yu
    Department of Digital Media Technology, Hangzhou Dianzi University, Hangzhou, 310018, China. Electronic address: jyyu@hdu.edu.cn.
  • Yigang Wang
    Department of Digital Media Technology, Hangzhou Dianzi University, Hangzhou, 310018, China. Electronic address: ygwang@hdu.edu.cn.