Comparison of Individualized Rescue Luteal Phase Support Strategies with Vaginal and Combined Vaginal & Subcutaneous Progesterone Administration in Artificial Frozen-Thawed Blastocyst Embryo Transfer Cycles Based on Serum Progesterone levels.

Journal: Frontiers in endocrinology
PMID: 39897956

Abstract

OBJECTIVES: Hormone replacement therapy (HRT) frozen embryo transfer (FET) cycles are common in assisted reproductive techniques. As the corpus luteum is absent in these cycles, luteal phase support is provided by administering progesterone (P4) through transvaginal, parenteral, or oral routes. Low serum levels of P4 (below 9-10 ng/mL) on the day before embryo transfer (ET) have been associated with unfavorable cycle outcomes. The aim of this study is to investigate whether individualizing luteal support through rescue protocols in patients with low serum P4 levels improves pregnancy outcomes in HRT-FET cycles.

Authors

  • Secil Irem Arik Alpcetin
    Department of Obstetrics and Gynecology, Gazi University, Ankara, Türkiye.
  • Onur Ince
    Department of Obstetrics and Gynecology, Hacettepe University, Ankara, Türkiye.
  • Bengisu Akcay
    Department of Obstetrics and Gynecology, Gazi University, Ankara, Türkiye.
  • Munire Funda Cevher Akdulum
    Department of Obstetrics and Gynecology, Gazi University, Ankara, Türkiye.
  • Erhan Demirdag
    Department of Obstetrics and Gynecology, Gazi University, Ankara, Türkiye.
  • Ahmet Erdem
    Department of Obstetrics and Gynecology, Gazi University, Ankara, Türkiye.
  • Mehmet Erdem
    Department of Obstetrics and Gynecology, Gazi University, Ankara, Türkiye.

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