Dental anomaly detection using intraoral photos via deep learning.

Journal: Scientific reports
Published Date:

Abstract

Children with orofacial clefting (OFC) present with a wide range of dental anomalies. Identifying these anomalies is vital to understand their etiology and to discern the complex phenotypic spectrum of OFC. Such anomalies are currently identified using intra-oral exams by dentists, a costly and time-consuming process. We claim that automating the process of anomaly detection using deep neural networks (DNNs) could increase efficiency and provide reliable anomaly detection while potentially increasing the speed of research discovery. This study characterizes the use of` DNNs to identify dental anomalies by training a DNN model using intraoral photographs from the largest international cohort to date of children with nonsyndromic OFC and controls (OFC1). In this project, the intraoral images were submitted to a Convolutional Neural Network model to perform multi-label multi-class classification of 10 dental anomalies. The network predicts whether an individual exhibits any of the 10 anomalies and can do so significantly faster than a human rater can. For all but three anomalies, F1 scores suggest that our model performs competitively at anomaly detection when compared to a dentist with 8 years of clinical experience. In addition, we use saliency maps to provide a post-hoc interpretation for our model's predictions. This enables dentists to examine and verify our model's predictions.

Authors

  • Ronilo Ragodos
    Department of Management Sciences, Tippie College of Business, University of Iowa, Iowa City, IA, USA.
  • Tong Wang
    School of Public Health, Shanxi Medical University, Taiyuan 030000, China; Key Laboratory of Coal Environmental Pathogenicity and Prevention (Shanxi Medical University), Ministry of Education, Taiyuan 030000, China.
  • Carmencita Padilla
    Department of Pediatrics, University of the Philippines Manila, Manilla, Philippines.
  • Jacqueline T Hecht
    Department of Pediatrics, University of Texas Health Science Center at Houston, Houston, TX, USA.
  • Fernando A Poletta
    ECLAMC at Center for Medical Education and Clinical Research, CEMIC-CONICET, Buenos Aires, Argentina.
  • Iêda M Orioli
    ECLAMC at Department of Genetics, Institute of Biology, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
  • Carmen J Buxó
    Dental and Craniofacial Genomics Core, School of Dental Medicine, University of Puerto Rico, San Juan, PR, USA.
  • Azeez Butali
    Department of Oral Pathology, Radiology, and Medicine, University of Iowa, Iowa City, IA, USA.
  • Consuelo Valencia-Ramirez
    Clinica Noel, Medellín, Colombia.
  • Claudia Restrepo Muñeton
    Clinica Noel, Medellín, Colombia.
  • George L Wehby
    Department of Health Management and Policy, College of Public Health, University of Iowa, Iowa City, IA, USA.
  • Seth M Weinberg
    Center for Craniofacial and Dental Genetics, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
  • Mary L Marazita
    Center for Craniofacial and Dental Genetics, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
  • Lina M Moreno Uribe
    The Iowa Institute for Oral Health Research, College of Dentistry, University of Iowa, Iowa City, IA, USA.
  • Brian J Howe
    The Iowa Institute for Oral Health Research, College of Dentistry, University of Iowa, Iowa City, IA, USA. brian-howe@uiowa.edu.